3CL2

N1 Neuraminidase N294S + Oseltamivir

Summary for 3CL2

Related3CKZ 3CL0
DescriptorNeuraminidase, (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid (2 entities in total)
Functional Keywordsn1, neuraminidase, n294s, oseltamivir, glycosidase, hydrolase, membrane, transmembrane, virion, viral protein
Biological sourceInfluenza A virus (A/Viet Nam/1203/2004(H5N1))
Total number of polymer chains8
Total molecular weight339537.94
Authors
Collins, P.,Haire, L.F.,Lin, Y.P.,Liu, J.,Russell, R.J.,Walker, P.A.,Skehel, J.J.,Martin, S.R.,Hay, A.J.,Gamblin, S.J. (deposition date: 2008-03-18, release date: 2008-05-20, Last modification date: 2018-08-22)
Primary citation
Collins, P.J.,Haire, L.F.,Lin, Y.P.,Liu, J.,Russell, R.J.,Walker, P.A.,Skehel, J.J.,Martin, S.R.,Hay, A.J.,Gamblin, S.J.
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.
Nature, 453:1258-1261, 2008
PubMed: 18480754 (PDB entries with the same primary citation)
DOI: 10.1038/nature06956
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.538 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.255161.3%6.8%0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution