3CL2
N1 Neuraminidase N294S + Oseltamivir
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0046761 | biological_process | viral budding from plasma membrane |
| A | 0055036 | cellular_component | virion membrane |
| B | 0004308 | molecular_function | exo-alpha-sialidase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0046761 | biological_process | viral budding from plasma membrane |
| B | 0055036 | cellular_component | virion membrane |
| C | 0004308 | molecular_function | exo-alpha-sialidase activity |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0016020 | cellular_component | membrane |
| C | 0033644 | cellular_component | host cell membrane |
| C | 0046761 | biological_process | viral budding from plasma membrane |
| C | 0055036 | cellular_component | virion membrane |
| D | 0004308 | molecular_function | exo-alpha-sialidase activity |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0016020 | cellular_component | membrane |
| D | 0033644 | cellular_component | host cell membrane |
| D | 0046761 | biological_process | viral budding from plasma membrane |
| D | 0055036 | cellular_component | virion membrane |
| E | 0004308 | molecular_function | exo-alpha-sialidase activity |
| E | 0005975 | biological_process | carbohydrate metabolic process |
| E | 0016020 | cellular_component | membrane |
| E | 0033644 | cellular_component | host cell membrane |
| E | 0046761 | biological_process | viral budding from plasma membrane |
| E | 0055036 | cellular_component | virion membrane |
| F | 0004308 | molecular_function | exo-alpha-sialidase activity |
| F | 0005975 | biological_process | carbohydrate metabolic process |
| F | 0016020 | cellular_component | membrane |
| F | 0033644 | cellular_component | host cell membrane |
| F | 0046761 | biological_process | viral budding from plasma membrane |
| F | 0055036 | cellular_component | virion membrane |
| G | 0004308 | molecular_function | exo-alpha-sialidase activity |
| G | 0005975 | biological_process | carbohydrate metabolic process |
| G | 0016020 | cellular_component | membrane |
| G | 0033644 | cellular_component | host cell membrane |
| G | 0046761 | biological_process | viral budding from plasma membrane |
| G | 0055036 | cellular_component | virion membrane |
| H | 0004308 | molecular_function | exo-alpha-sialidase activity |
| H | 0005975 | biological_process | carbohydrate metabolic process |
| H | 0016020 | cellular_component | membrane |
| H | 0033644 | cellular_component | host cell membrane |
| H | 0046761 | biological_process | viral budding from plasma membrane |
| H | 0055036 | cellular_component | virion membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE G39 A 800 |
| Chain | Residue |
| A | ARG118 |
| A | GLU119 |
| A | ASP151 |
| A | ARG152 |
| A | SER246 |
| A | ARG292 |
| A | TYR347 |
| A | ARG371 |
| A | TYR406 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE G39 B 801 |
| Chain | Residue |
| B | ARG118 |
| B | GLU119 |
| B | ASP151 |
| B | ARG152 |
| B | SER246 |
| B | GLU277 |
| B | ARG292 |
| B | TYR347 |
| B | ARG371 |
| B | TYR406 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE G39 C 802 |
| Chain | Residue |
| C | ARG118 |
| C | GLU119 |
| C | ASP151 |
| C | ARG152 |
| C | TRP178 |
| C | GLU276 |
| C | GLU277 |
| C | ARG292 |
| C | TYR347 |
| C | ARG371 |
| C | TYR406 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE G39 D 803 |
| Chain | Residue |
| D | ARG118 |
| D | GLU119 |
| D | ASP151 |
| D | ARG152 |
| D | TRP178 |
| D | SER246 |
| D | GLU277 |
| D | ARG292 |
| D | TYR347 |
| D | ARG371 |
| D | TYR406 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE G39 E 805 |
| Chain | Residue |
| E | ARG118 |
| E | GLU119 |
| E | ASP151 |
| E | ARG152 |
| E | TRP178 |
| E | GLU277 |
| E | ARG292 |
| E | TYR347 |
| E | ARG371 |
| E | TYR406 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE G39 F 806 |
| Chain | Residue |
| F | ARG118 |
| F | GLU119 |
| F | ASP151 |
| F | ARG152 |
| F | SER246 |
| F | GLU277 |
| F | ARG292 |
| F | TYR347 |
| F | ARG371 |
| F | TYR406 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE G39 G 807 |
| Chain | Residue |
| G | ARG118 |
| G | GLU119 |
| G | ASP151 |
| G | ARG152 |
| G | TRP178 |
| G | ARG224 |
| G | GLU276 |
| G | GLU277 |
| G | ARG292 |
| G | TYR347 |
| G | ARG371 |
| G | TYR406 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE G39 H 808 |
| Chain | Residue |
| H | ARG118 |
| H | GLU119 |
| H | ASP151 |
| H | ARG152 |
| H | TRP178 |
| H | GLU277 |
| H | ARG292 |
| H | TYR347 |
| H | ARG371 |
| H | TYR406 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16915235","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18480754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CKZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CL0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16915235","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18480754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CKZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CL0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16915235","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18480754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CKZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| A | ASP151 | |
| A | GLU277 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| B | ASP151 | |
| B | GLU277 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| C | ASP151 | |
| C | GLU277 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| D | ASP151 | |
| D | GLU277 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| E | ASP151 | |
| E | GLU277 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| F | ASP151 | |
| F | GLU277 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| G | ASP151 | |
| G | GLU277 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| H | ASP151 | |
| H | GLU277 |
