3CKI
Crystal structure of the TACE-N-TIMP-3 complex
Summary for 3CKI
Entry DOI | 10.2210/pdb3cki/pdb |
Descriptor | ADAM 17, Metalloproteinase inhibitor 3, ZINC ION, ... (5 entities in total) |
Functional Keywords | extra-cellular matrix, catalytic zinc, sa-sb loop, alternative splicing, cleavage on pair of basic residues, glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, sh3-binding, transmembrane, zymogen, disease mutation, extracellular matrix, metalloenzyme inhibitor, metalloprotease inhibitor, secreted, sensory transduction, vision, hydrolase, hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P78536 Secreted, extracellular space, extracellular matrix: P35625 |
Total number of polymer chains | 2 |
Total formula weight | 43016.13 |
Authors | Wisniewska, M.,Goettig, P.,Maskos, K.,Belouski, E.,Winters, D.,Hecht, R.,Black, R.,Bode, W. (deposition date: 2008-03-15, release date: 2008-08-05, Last modification date: 2023-08-30) |
Primary citation | Wisniewska, M.,Goettig, P.,Maskos, K.,Belouski, E.,Winters, D.,Hecht, R.,Black, R.,Bode, W. Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex. J.Mol.Biol., 381:1307-1319, 2008 Cited by PubMed: 18638486DOI: 10.1016/j.jmb.2008.06.088 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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