3CKI
Crystal structure of the TACE-N-TIMP-3 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ADAM 17 | polymer | 256 | 28954.5 | 1 | UniProt (P78536) Pfam (PF13688) In PDB | Homo sapiens (human) | A disintegrin and metalloproteinase domain 17, TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, CD156b antigen |
| 2 | B | Metalloproteinase inhibitor 3 | polymer | 121 | 13973.3 | 1 | UniProt (P35625) Pfam (PF00965) In PDB | Homo sapiens (human) | TIMP-3, Tissue inhibitor of metalloproteinases 3, Protein MIG-5 |
| 3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
A: 219 - 474 (UniProt: P78536)
| PDB | External Database | Details |
|---|---|---|
| Ala 266 | Ser 266 | engineered mutation |
| Gln 452 | Asn 452 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42927.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 88.4 | |
| All* | Total formula weight | 43016.1 |
