3CJO

Crystal structure of KSP in complex with inhibitor 30

3CJO の概要

• エントリーDOI: 10.2210/pdb3cjo/pdb
• 分子名称: Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: ksp, ksp-inhibitor complex, atp-binding, cell cycle, cell division, coiled coil, microtubule, mitosis, motor protein, nucleotide-binding, phosphoprotein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P52732
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83670.79

構造登録者

Yan, Y. (登録日: 2008-03-13, 公開日: 2008-07-01, 最終更新日: 2023-08-30)

• 主引用文献: Cox, C.D.,Coleman, P.J.,Breslin, M.J.,Whitman, D.B.,Garbaccio, R.M.,Fraley, M.E.,Buser, C.A.,Walsh, E.S.,Hamilton, K.,Schaber, M.D.,Lobell, R.B.,Tao, W.,Davide, J.P.,Diehl, R.E.,Abrams, M.T.,South, V.J.,Huber, H.E.,Torrent, M.,Prueksaritanont, T.,Li, C.,Slaughter, D.E.,Mahan, E.,Fernandez-Metzler, C.,Yan, Y.,Kuo, L.C.,Kohl, N.E.,Hartman, G.D.; Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.; J.Med.Chem., 51:4239-4252, 2008; PubMed: 18578472; DOI: 10.1021/jm800386y

実験手法

X-RAY DIFFRACTION (2.28 Å)