3CHR

Crystal structure of leukotriene A4 hydrolase in complex with 4-amino-N-[4-(phenylmethoxy)phenyl]-butanamide

3CHR の概要

• エントリーDOI: 10.2210/pdb3chr/pdb
• 関連するPDBエントリー: 1GW6 1H19 1HS6 1SQM 2VJ8 3CHO 3CHP 3CHQ 3CHS
• 分子名称: Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (6 entities in total)
• 機能のキーワード: epoxide hydrolase, alpha-beta protein, leukotriene biosynthesis, metalloprotease, inhibitor complex, alternative splicing, cytoplasm, metal-binding, multifunctional enzyme, zinc, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 69824.66

構造登録者

Thunnissen, M.M.G.M.,Adler, M.,Whitlow, M. (登録日: 2008-03-10, 公開日: 2008-04-22, 最終更新日: 2024-02-21)

• 主引用文献: Kirkland, T.A.,Adler, M.,Bauman, J.G.,Chen, M.,Haeggstrom, J.Z.,King, B.,Kochanny, M.J.,Liang, A.M.,Mendoza, L.,Phillips, G.B.,Thunnissen, M.,Trinh, L.,Whitlow, M.,Ye, B.,Ye, H.,Parkinson, J.,Guilford, W.J.; Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.; Bioorg.Med.Chem., 16:4963-4983, 2008; PubMed: 18394906; DOI: 10.1016/j.bmc.2008.03.042

実験手法

X-RAY DIFFRACTION (2.2 Å)