3CDW

Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with protein primer VPg and a pyrophosphate

Summary for 3CDW

• Entry DOI: 10.2210/pdb3cdw/pdb
• Related: 1XR5 2E9Z 2F8E 2ILZ 3CDU
• Descriptor: RNA-directed RNA polymerase 3D-POL, Protein 3B, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: coxsackievirus, rna-dependent rna polymerase, protein primer, vpg, vizier viral enzymes involved in replication, transferase-viral protein complex, transferase/viral protein
• Biological source: Coxsackievirus B3; More
• Cellular location: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P03313 P03313
• Total number of polymer chains: 2
• Total formula weight: 58955.59

Authors

Gruez, A.,Selisko, B.,Roberts, M.,Bricogne, G.,Bussetta, C.,Canard, B. (deposition date: 2008-02-27, release date: 2008-07-22, Last modification date: 2023-11-01)

• Primary citation: Gruez, A.,Selisko, B.,Roberts, M.,Bricogne, G.,Bussetta, C.,Jabafi, I.,Coutard, B.,De Palma, A.M.,Neyts, J.,Canard, B.; The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases; J.Virol., 82:9577-9590, 2008; PubMed: 18632861; DOI: 10.1128/JVI.00631-08

Experimental method

X-RAY DIFFRACTION (2.5 Å)