3CDW

Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with protein primer VPg and a pyrophosphate

3CDW の概要

• エントリーDOI: 10.2210/pdb3cdw/pdb
• 関連するPDBエントリー: 1XR5 2E9Z 2F8E 2ILZ 3CDU
• 分子名称: RNA-directed RNA polymerase 3D-POL, Protein 3B, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: coxsackievirus, rna-dependent rna polymerase, protein primer, vpg, vizier viral enzymes involved in replication, transferase-viral protein complex, transferase/viral protein
• 由来する生物種: Coxsackievirus B3; 詳細
• 細胞内の位置: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P03313 P03313
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58955.59

構造登録者

Gruez, A.,Selisko, B.,Roberts, M.,Bricogne, G.,Bussetta, C.,Canard, B. (登録日: 2008-02-27, 公開日: 2008-07-22, 最終更新日: 2023-11-01)

• 主引用文献: Gruez, A.,Selisko, B.,Roberts, M.,Bricogne, G.,Bussetta, C.,Jabafi, I.,Coutard, B.,De Palma, A.M.,Neyts, J.,Canard, B.; The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases; J.Virol., 82:9577-9590, 2008; PubMed: 18632861; DOI: 10.1128/JVI.00631-08

実験手法

X-RAY DIFFRACTION (2.5 Å)