3CD8

X-ray Structure of c-Met with triazolopyridazine Inhibitor.

3CD8 の概要

• エントリーDOI: 10.2210/pdb3cd8/pdb
• 関連するPDBエントリー: 3CCN
• 分子名称: Hepatocyte growth factor receptor, 7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline (3 entities in total)
• 機能のキーワード: c-met, kinase, triazolopyridazine, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35730.31

構造登録者

Bellon, S.F.,Albrecht, B.K.,Harmange, J.-C.,Bauer, D.,Choquette, D.,Dussault, I. (登録日: 2008-02-26, 公開日: 2008-04-29, 最終更新日: 2023-08-30)

• 主引用文献: Albrecht, B.K.,Harmange, J.C.,Bauer, D.,Berry, L.,Bode, C.,Boezio, A.A.,Chen, A.,Choquette, D.,Dussault, I.,Fridrich, C.,Hirai, S.,Hoffman, D.,Larrow, J.F.,Kaplan-Lefko, P.,Lin, J.,Lohman, J.,Long, A.M.,Moriguchi, J.,O'Connor, A.,Potashman, M.H.,Reese, M.,Rex, K.,Siegmund, A.,Shah, K.,Shimanovich, R.,Springer, S.K.,Teffera, Y.,Yang, Y.,Zhang, Y.,Bellon, S.F.; Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase.; J.Med.Chem., 51:2879-2882, 2008; PubMed: 18426196; DOI: 10.1021/jm800043g

実験手法

X-RAY DIFFRACTION (2 Å)