3CBZ

The Dvl2 PDZ Domain in Complex with the N2 Inhibitory Peptide

3CBZ の概要

• エントリーDOI: 10.2210/pdb3cbz/pdb
• 関連するPDBエントリー: 3CBX 3CBY 3CC0
• 分子名称: Dishevelled-2, PHOSPHATE ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: pdz domain, phage derived high affinity ligand, cytoplasm, developmental protein, phosphoprotein, wnt signaling pathway, signaling protein, protein binding
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side : O14641
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11644.02

構造登録者

Appleton, B.A.,Wiesmann, C. (登録日: 2008-02-23, 公開日: 2009-03-03, 最終更新日: 2023-08-30)

主引用文献

Zhang, Y.,Appleton, B.A.,Wiesmann, C.,Lau, T.,Costa, M.,Hannoush, R.N.,Sidhu, S.S.
Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5:217-219, 2009

PubMed Abstract: Dishevelled proteins are key regulators of Wnt signaling pathways that have been implicated in the progression of human cancers. We found that the binding cleft of the Dishevelled PDZ domain is more flexible than those of canonical PDZ domains and enables recognition of both C-terminal and internal peptides. These peptide ligands inhibit Wnt/beta-catenin signaling in cells, showing that Dishevelled PDZ domains are potential targets for small-molecule cancer therapeutics.

PubMed: 19252499
DOI: 10.1038/nchembio.152

実験手法

X-RAY DIFFRACTION (1.38 Å)