3CBL
Crystal structure of human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide
3CBL の概要
エントリーDOI | 10.2210/pdb3cbl/pdb |
分子名称 | Proto-oncogene tyrosine-protein kinase Fes/Fps, Synthetic peptide, STAUROSPORINE, ... (4 entities in total) |
機能のキーワード | fes, v-fes, fujinami, avian sarcoma, viral, oncogene, feline sarcoma virus, sgc, structural genomics consortium, atp-binding, kinase, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 44807.37 |
構造登録者 | Filippakopoulos, P.,Salah, E.,Cooper, C.,Picaud, S.S.,Elkins, J.M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2008-02-22, 公開日: 2008-03-04, 最終更新日: 2023-08-30) |
主引用文献 | Filippakopoulos, P.,Kofler, M.,Hantschel, O.,Gish, G.D.,Grebien, F.,Salah, E.,Neudecker, P.,Kay, L.E.,Turk, B.E.,Superti-Furga, G.,Pawson, T.,Knapp, S. Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation Cell(Cambridge,Mass.), 134:793-803, 2008 Cited by PubMed: 18775312DOI: 10.1016/j.cell.2008.07.047 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.75 Å) |
構造検証レポート
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