3C7P

Crystal structure of human carbonic anhydrase II in complex with STX237

Summary for 3C7P

Entry DOI	10.2210/pdb3c7p/pdb
Related	2gd8 3bet
Descriptor	Carbonic anhydrase 2, ZINC ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywords	protein-inhibitor complex, disease mutation, lyase, metal-binding
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	30273.27
Authors	Di Fiore, A.,De Simone, G. (deposition date: 2008-02-08, release date: 2009-01-13, Last modification date: 2023-11-01)
Primary citation	Woo, L.W.L.,Fischer, D.S.,Sharland, C.M.,Trusselle, M.,Foster, P.A.,Chander, S.K.,Di Fiore, A.,Supuran, C.T.,De Simone, G.,Purohit, A.,Reed, M.J.,Potter, B.V.L. Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography Mol.Cancer Ther., 7:2435-2444, 2008 Cited by PubMed: 18723489 DOI: 10.1158/1535-7163.MCT-08-0195 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation