3C5E

Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in complex with ATP

3C5E の概要

• エントリーDOI: 10.2210/pdb3c5e/pdb
• 関連するPDBエントリー: 3B7W
• 分子名称: Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor, MAGNESIUM ION, CHLORIDE ION, ... (8 entities in total)
• 機能のキーワード: middle-chain acyl-coa synthetase, xenobiotic/medium-chain fatty acid-coa ligase, structural genomics consortium, sgc, atp-binding, fatty acid metabolism, lipid metabolism, magnesium, metal-binding, mitochondrion, nucleotide-binding polymorphism, transit peptide, ligase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion matrix : Q08AH3
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 64175.50

構造登録者

Pilka, E.S.,Kochan, G.T.,Bhatia, C.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Oppermann, U.,Structural Genomics Consortium (SGC) (登録日: 2008-01-31, 公開日: 2008-02-26, 最終更新日: 2023-08-30)

• 主引用文献: Kochan, G.,Pilka, E.S.,von Delft, F.,Oppermann, U.,Yue, W.W.; Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.; J.Mol.Biol., 388:997-1008, 2009; PubMed: 19345228; DOI: 10.1016/j.jmb.2009.03.064

実験手法

X-RAY DIFFRACTION (1.6 Å)