3C4H

Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313

Summary for 3C4H

• Entry DOI: 10.2210/pdb3c4h/pdb
• Related: 2PA9 3C49
• Descriptor: Poly(ADP-ribose) polymerase 3, 2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: enzyme-inhibitor complex, catalytic fragment, structural genomics, structural genomics consortium, sgc, glycosyltransferase, nad, nucleus, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q9Y6F1
• Total number of polymer chains: 1
• Total formula weight: 40012.45

Authors

Lehtio, L.,Collins, R.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Busam, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Herman, M.D.,Johansson, A.,Johansson, I.,Kallas, A.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van den Berg, S.,Welin, M.,Weigelt, J.,Structural Genomics Consortium (SGC) (deposition date: 2008-01-30, release date: 2008-02-12, Last modification date: 2023-08-30)

• Primary citation: Lehtio, L.,Jemth, A.S.,Collins, R.,Loseva, O.,Johansson, A.,Markova, N.,Hammarstrom, M.,Flores, A.,Holmberg-Schiavone, L.,Weigelt, J.,Helleday, T.,Schuler, H.,Karlberg, T.; Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.; J.Med.Chem., 52:3108-3111, 2009; PubMed: 19354255; DOI: 10.1021/jm900052j

Experimental method

X-RAY DIFFRACTION (2.1 Å)