3C4F

FGFR TYROSINE KINASE DOMAIN IN COMPLEX WITH 3-(3-methoxybenzyl)-7-azaindole

3C4F の概要

• エントリーDOI: 10.2210/pdb3c4f/pdb
• 関連するPDBエントリー: 3C4C 3C4D 3C4E
• 分子名称: Basic fibroblast growth factor receptor 1, 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine (3 entities in total)
• 機能のキーワード: fibroblast growth factor receptor, tyrosine kinase domain, receptor tyrosine kinase, fgfr1, fgfr, alternative splicing, atp-binding, chromosomal rearrangement, disease mutation, dwarfism, glycoprotein, heparin-binding, immunoglobulin domain, kallmann syndrome, membrane, nucleotide-binding, phosphoprotein, polymorphism, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P11362
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69452.03

構造登録者

Zhang, K.Y.J.,Wang, W. (登録日: 2008-01-29, 公開日: 2008-02-26, 最終更新日: 2024-02-21)

• 主引用文献: Tsai, J.,Lee, J.T.,Wang, W.,Zhang, J.,Cho, H.,Mamo, S.,Bremer, R.,Gillette, S.,Kong, J.,Haass, N.K.,Sproesser, K.,Li, L.,Smalley, K.S.,Fong, D.,Zhu, Y.L.,Marimuthu, A.,Nguyen, H.,Lam, B.,Liu, J.,Cheung, I.,Rice, J.,Suzuki, Y.,Luu, C.,Settachatgul, C.,Shellooe, R.,Cantwell, J.,Kim, S.H.,Schlessinger, J.,Zhang, K.Y.,West, B.L.,Powell, B.,Habets, G.,Zhang, C.,Ibrahim, P.N.,Hirth, P.,Artis, D.R.,Herlyn, M.,Bollag, G.; Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity; Proc.Natl.Acad.Sci.Usa, 105:3041-3046, 2008; PubMed: 18287029; DOI: 10.1073/pnas.0711741105

実験手法

X-RAY DIFFRACTION (2.07 Å)