Structure of RNaseIIIb and dsRNA binding domains of mouse Dicer

Summary for 3C4B

DescriptorEndoribonuclease Dicer (2 entities in total)
Functional Keywordsrnase, dsrna binding protein, atp-binding, endonuclease, helicase, hydrolase, nuclease, nucleotide-binding, phosphoprotein, rna-binding, rna-mediated gene silencing
Biological sourceMus musculus (house mouse)
Cellular locationCytoplasm (By similarity) Q8R418
Total number of polymer chains1
Total molecular weight30971.91
Lee, J.K.,Du, Z.,Tjhen, R.J.,Stroud, R.M.,James, T.L. (deposition date: 2008-01-29, release date: 2008-02-19, Last modification date: 2011-07-13)
Primary citation
Du, Z.,Lee, J.K.,Tjhen, R.,Stroud, R.M.,James, T.L.
Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage.
Proc.Natl.Acad.Sci.Usa, 105:2391-2396, 2008
PubMed: 18268334 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0711506105
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.215702.8%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution