3C2M
Ternary complex of DNA POLYMERASE BETA with a G:dAPCPP mismatch in the active site
Summary for 3C2M
Entry DOI | 10.2210/pdb3c2m/pdb |
Related | 2FMP 3C2K 3C2L |
Descriptor | DNA (5'-D(*DCP*DCP*DGP*DAP*DCP*DGP*DGP*DCP*DGP*DCP*DAP*DTP*DCP*DAP*DGP*DC)-3'), DNA (5'-D(*DGP*DCP*DTP*DGP*DAP*DTP*DGP*DCP*DGP*DC)-3'), DNA (5'-D(P*DGP*DTP*DCP*DGP*DG)-3'), ... (9 entities in total) |
Functional Keywords | nucleotidyl transferase, dna polymerase, misincorporation, dna damage, dna repair, dna replication, dna synthesis, dna-binding, dna-directed dna polymerase, lyase, magnesium, metal-binding, nucleotidyltransferase, nucleus, polymorphism, sodium, transferase, lyase-dna complex, lyase/dna |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P06746 |
Total number of polymer chains | 4 |
Total formula weight | 48843.72 |
Authors | Batra, V.K.,Beard, W.A.,Shock, D.D.,Pedersen, L.C.,Wilson, S.H. (deposition date: 2008-01-25, release date: 2008-05-20, Last modification date: 2023-08-30) |
Primary citation | Batra, V.K.,Beard, W.A.,Shock, D.D.,Pedersen, L.C.,Wilson, S.H. Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Mol.Cell, 30:315-324, 2008 Cited by PubMed: 18471977DOI: 10.1016/j.molcel.2008.02.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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