3C2L

Ternary complex of DNA POLYMERASE BETA with a C:DAPCPP mismatch in the active site

Summary for 3C2L

• Entry DOI: 10.2210/pdb3c2l/pdb
• Related: 2FMP 3C2K 3C2M
• Descriptor: DNA (5'-D(*DCP*DCP*DGP*DAP*DCP*DCP*DGP*DCP*DGP*DCP*DAP*DTP*DCP*DAP*DGP*DC)-3'), DNA (5'-D(*DGP*DCP*DTP*DGP*DAP*DTP*DGP*DCP*DGP*DC)-3'), DNA (5'-D(P*DGP*DTP*DCP*DGP*DG)-3'), ... (8 entities in total)
• Functional Keywords: nucleotidyl transferase, dna polymerase, misincorporation, dna damage, dna repair, dna replication, dna synthesis, dna-binding, dna-directed dna polymerase, lyase, magnesium, metal-binding, nucleotidyltransferase, nucleus, polymorphism, sodium, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 48532.66

Authors

Batra, V.K.,Beard, W.A.,Shock, D.D.,Pedersen, L.C.,Wilson, S.H. (deposition date: 2008-01-25, release date: 2008-05-20, Last modification date: 2023-08-30)

• Primary citation: Batra, V.K.,Beard, W.A.,Shock, D.D.,Pedersen, L.C.,Wilson, S.H.; Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation.; Mol.Cell, 30:315-324, 2008; PubMed: 18471977; DOI: 10.1016/j.molcel.2008.02.025

Experimental method

X-RAY DIFFRACTION (2.6 Å)