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3C0A

Lactobacillus CASEI Thymidylate Synthase Ternary Complex with DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 2

Summary for 3C0A
Entry DOI10.2210/pdb3c0a/pdb
Related1TLS 3BNZ 3BYX 3BZ0 3C06
DescriptorThymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-(2-chloropyridin-4-yl)-4-methyl-1H-isoindole-1,3(2H)-dione, ... (4 entities in total)
Functional Keywordsmethyltransferase, structure-based drug design, nucleotide biosynthesis, transferase
Biological sourceLactobacillus casei
Cellular locationCytoplasm: P00469
Total number of polymer chains1
Total formula weight37211.32
Authors
Leone, R.,Mangani, S.,Cancian, L.,Costi, M.P.,Luciani, R.,Ferrari, S. (deposition date: 2008-01-19, release date: 2009-01-20, Last modification date: 2023-11-01)
Primary citationMangani, S.,Cancian, L.,Leone, R.,Pozzi, C.,Lazzari, S.,Luciani, R.,Ferrari, S.,Costi, M.P.
Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening
J.Med.Chem., 54:5454-5467, 2011
Cited by
PubMed: 21696158
DOI: 10.1021/jm2005018
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

數據於2024-03-27公開中

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