3C0A
Lactobacillus CASEI Thymidylate Synthase Ternary Complex with DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 2
Summary for 3C0A
Entry DOI | 10.2210/pdb3c0a/pdb |
Related | 1TLS 3BNZ 3BYX 3BZ0 3C06 |
Descriptor | Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-(2-chloropyridin-4-yl)-4-methyl-1H-isoindole-1,3(2H)-dione, ... (4 entities in total) |
Functional Keywords | methyltransferase, structure-based drug design, nucleotide biosynthesis, transferase |
Biological source | Lactobacillus casei |
Cellular location | Cytoplasm: P00469 |
Total number of polymer chains | 1 |
Total formula weight | 37211.32 |
Authors | Leone, R.,Mangani, S.,Cancian, L.,Costi, M.P.,Luciani, R.,Ferrari, S. (deposition date: 2008-01-19, release date: 2009-01-20, Last modification date: 2023-11-01) |
Primary citation | Mangani, S.,Cancian, L.,Leone, R.,Pozzi, C.,Lazzari, S.,Luciani, R.,Ferrari, S.,Costi, M.P. Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening J.Med.Chem., 54:5454-5467, 2011 Cited by PubMed: 21696158DOI: 10.1021/jm2005018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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