3C0A

Lactobacillus CASEI Thymidylate Synthase Ternary Complex with DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 2

3C0A の概要

• エントリーDOI: 10.2210/pdb3c0a/pdb
• 関連するPDBエントリー: 1TLS 3BNZ 3BYX 3BZ0 3C06
• 分子名称: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-(2-chloropyridin-4-yl)-4-methyl-1H-isoindole-1,3(2H)-dione, ... (4 entities in total)
• 機能のキーワード: methyltransferase, structure-based drug design, nucleotide biosynthesis, transferase
• 由来する生物種: Lactobacillus casei
• 細胞内の位置: Cytoplasm: P00469
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37211.32

構造登録者

Leone, R.,Mangani, S.,Cancian, L.,Costi, M.P.,Luciani, R.,Ferrari, S. (登録日: 2008-01-19, 公開日: 2009-01-20, 最終更新日: 2023-11-01)

• 主引用文献: Mangani, S.,Cancian, L.,Leone, R.,Pozzi, C.,Lazzari, S.,Luciani, R.,Ferrari, S.,Costi, M.P.; Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening; J.Med.Chem., 54:5454-5467, 2011; PubMed: 21696158; DOI: 10.1021/jm2005018

実験手法

X-RAY DIFFRACTION (2.4 Å)