3BWK

Crystal Structure of Falcipain-3 with Its inhibitor, K11017

Summary for 3BWK

Entry DOI	10.2210/pdb3bwk/pdb
Related	1AIM 1YVB 2GHU 3BPF 3BPM
Descriptor	Cysteine protease falcipain-3, N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	falcipain, malaria, cysteine protease, hydrolase
Biological source	Plasmodium falciparum
Total number of polymer chains	4
Total formula weight	112101.40
Authors	Kerr, I.,Lee, J.H.,Brinen, L.S. (deposition date: 2008-01-09, release date: 2009-01-20, Last modification date: 2023-08-30)
Primary citation	Kerr, I.D.,Lee, J.H.,Farady, C.J.,Marion, R.,Rickert, M.,Sajid, M.,Pandey, K.C.,Caffrey, C.R.,Legac, J.,Hansell, E.,McKerrow, J.H.,Craik, C.S.,Rosenthal, P.J.,Brinen, L.S. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J.Biol.Chem., 284:25697-25703, 2009 Cited by PubMed: 19620707 DOI: 10.1074/jbc.M109.014340 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.42 Å)

Structure validation