Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE C1P A 300 |
| Chain | Residue |
| A | GLN45 |
| A | TYR93 |
| A | ASN182 |
| A | HIS183 |
| A | TRP215 |
| A | HOH422 |
| A | GLY49 |
| A | CYS51 |
| A | TRP52 |
| A | ASN87 |
| A | CYS89 |
| A | TYR90 |
| A | GLY91 |
| A | GLY92 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | LYS20 |
| A | LYS25 |
| A | LEU26 |
| A | ARG28 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE C1P B 300 |
| Chain | Residue |
| B | GLN45 |
| B | GLY49 |
| B | CYS51 |
| B | TRP52 |
| B | ASN87 |
| B | CYS89 |
| B | TYR90 |
| B | GLY91 |
| B | GLY92 |
| B | TYR93 |
| B | ASN182 |
| B | HIS183 |
| B | TRP215 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| B | LYS20 |
| B | ALA24 |
| B | LEU26 |
| B | ARG28 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| A | ARG127 |
| A | HOH454 |
| B | ARG127 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE C1P C 300 |
| Chain | Residue |
| C | GLN45 |
| C | GLY49 |
| C | CYS51 |
| C | TRP52 |
| C | ASN87 |
| C | CYS89 |
| C | TYR90 |
| C | GLY91 |
| C | GLY92 |
| C | TYR93 |
| C | PRO181 |
| C | ASN182 |
| C | HIS183 |
| C | TRP215 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 301 |
| Chain | Residue |
| C | LYS20 |
| C | LYS25 |
| C | LEU26 |
| C | ARG28 |
| C | HOH318 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE C1P D 300 |
| Chain | Residue |
| B | ASP163 |
| D | GLN45 |
| D | GLY49 |
| D | CYS51 |
| D | TRP52 |
| D | ASN87 |
| D | CYS89 |
| D | TYR90 |
| D | GLY91 |
| D | GLY92 |
| D | TYR93 |
| D | PRO181 |
| D | ASN182 |
| D | HIS183 |
| D | TRP215 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 301 |
| Chain | Residue |
| D | LYS20 |
| D | ALA24 |
| D | LEU26 |
| D | ARG28 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QAlCGSCWAfSS |
| Chain | Residue | Details |
| A | GLN45-SER56 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 68 |
| Details | Motif: {"description":"Nose motif; required for the correct folding of the mature form","evidences":[{"source":"UniProtKB","id":"Q8I6U4","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Motif: {"description":"Arm motif; binds to host hemoglobin and required for the inhibitory interaction between the propeptide and the catalytic domain","evidences":[{"source":"UniProtKB","id":"Q8I6U4","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10088","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10089","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10090","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | CYS51 | |
| A | HIS183 | |
| A | ASN213 | |
| site_id | CSA10 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| B | CYS51 | |
| B | HIS183 | |
| B | GLN45 | |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| C | CYS51 | |
| C | HIS183 | |
| C | GLN45 | |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| D | CYS51 | |
| D | HIS183 | |
| D | GLN45 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| B | CYS51 | |
| B | HIS183 | |
| B | ASN213 | |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| C | CYS51 | |
| C | HIS183 | |
| C | ASN213 | |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| D | CYS51 | |
| D | HIS183 | |
| D | ASN213 | |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | HIS183 | |
| A | GLN45 | |
| A | ASN213 | |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| B | HIS183 | |
| B | GLN45 | |
| B | ASN213 | |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| C | HIS183 | |
| C | GLN45 | |
| C | ASN213 | |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| D | HIS183 | |
| D | GLN45 | |
| D | ASN213 | |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | CYS51 | |
| A | HIS183 | |
| A | GLN45 | |
