3BVA
Cystal structure of HIV-1 Active Site Mutant D25N and p2-NC analog inhibitor
Summary for 3BVA
Entry DOI | 10.2210/pdb3bva/pdb |
Related | 3BVB |
Related PRD ID | PRD_000398 |
Descriptor | Protease (Retropepsin), GLYCEROL, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, ... (4 entities in total) |
Functional Keywords | drug resistance, hiv-1, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22526.65 |
Authors | Liu, F.,Weber, I.T. (deposition date: 2008-01-05, release date: 2008-04-01, Last modification date: 2023-08-30) |
Primary citation | Sayer, J.M.,Liu, F.,Ishima, R.,Weber, I.T.,Louis, J.M. Effect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 Protease. J.Biol.Chem., 283:13459-13470, 2008 Cited by PubMed: 18281688DOI: 10.1074/jbc.M708506200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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