3BVB

Cystal structure of HIV-1 Active Site Mutant D25N and inhibitor Darunavir

Summary for 3BVB

Entry DOI	10.2210/pdb3bvb/pdb
Related	3BVA
Descriptor	Protease (Retropepsin), SODIUM ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	drug resistance; hiv-1; d25n, mutant, aids, aspartyl protease, capsid maturation, core protein, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc-finger
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	2
Total formula weight	22177.58
Authors	Liu, F.,Weber, I.T. (deposition date: 2008-01-05, release date: 2008-04-01, Last modification date: 2023-08-30)
Primary citation	Sayer, J.M.,Liu, F.,Ishima, R.,Weber, I.T.,Louis, J.M. Effect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 Protease. J.Biol.Chem., 283:13459-13470, 2008 Cited by PubMed: 18281688 DOI: 10.1074/jbc.M708506200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation