3BVA
Cystal structure of HIV-1 Active Site Mutant D25N and p2-NC analog inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Protease (Retropepsin) | polymer | 99 | 10739.7 | 2 | UniProt (P03367) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | (PR) |
2 | A, B | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
3 | B | N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide | non-polymer | 771.0 | 1 | BIRD (PRD_000398) Chemie (2NC) | |||
4 | water | water | 18.0 | 234 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 507 | engineered mutation |
Asn 25 | Asp 525 | engineered mutation |
Ile 33 | Leu 533 | engineered mutation |
Ile 63 | Leu 563 | engineered mutation |
Ala 67 | Cys 567 | engineered mutation |
Ala 95 | Cys 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 21479.4 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1047.3 | |
All* | Total formula weight | 22526.6 |