3BVA

Cystal structure of HIV-1 Active Site Mutant D25N and p2-NC analog inhibitor

Summary for 3BVA

• Entry DOI: 10.2210/pdb3bva/pdb
• Related: 3BVB
• Related PRD ID: PRD_000398
• Descriptor: Protease (Retropepsin), GLYCEROL, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, ... (4 entities in total)
• Functional Keywords: drug resistance, hiv-1, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• Total number of polymer chains: 2
• Total formula weight: 22526.65

Authors

Liu, F.,Weber, I.T. (deposition date: 2008-01-05, release date: 2008-04-01, Last modification date: 2023-08-30)

• Primary citation: Sayer, J.M.,Liu, F.,Ishima, R.,Weber, I.T.,Louis, J.M.; Effect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 Protease.; J.Biol.Chem., 283:13459-13470, 2008; PubMed: 18281688; DOI: 10.1074/jbc.M708506200

Experimental method

X-RAY DIFFRACTION (1.05 Å)