3BV9

Structure of Thrombin Bound to the Inhibitor FM19

3BV9 の概要

• エントリーDOI: 10.2210/pdb3bv9/pdb
• 関連するPDBエントリー: 1SFQ
• 関連するBIRD辞書のPRD_ID: PRD_000276
• 分子名称: Thrombin light chain, Thrombin heavy chain, FM19 inhibitor, ... (7 entities in total)
• 機能のキーワード: serine protease, acute phase, blood coagulation, gamma-carboxyglutamic acid, glycoprotein, kringle, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space: P00734 P00734
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 34582.88

構造登録者

Nieman, M.T.,Burke, F.,Warnock, M.,Zhou, Y.,Sweigert, J.,Chen, A.,Ricketts, D.,Lucchesi, B.R.,Chen, Z.,Di Cera, E.,Hilfinger, J.,Mosberg, H.I.,Schmaier, A.H. (登録日: 2008-01-05, 公開日: 2008-03-04, 最終更新日: 2023-08-30)

主引用文献

Nieman, M.T.,Burke, F.,Warnock, M.,Zhou, Y.,Sweigart, J.,Chen, A.,Ricketts, D.,Lucchesi, B.R.,Chen, Z.,Di Cera, E.,Hilfinger, J.,Kim, J.S.,Mosberg, H.I.,Schmaier, A.H.
Thrombostatin FM compounds: direct thrombin inhibitors - mechanism of action in vitro and in vivo.
J.Thromb.Haemost., 6:837-845, 2008

PubMed Abstract: Novel pentapeptides called Thrombostatin FM compounds consisting mostly of D-isomers and unusual amino acids were prepared based upon the stable angiotensin converting enzyme breakdown product of bradykinin - RPPGF.

PubMed: 18315550
DOI: 10.1111/j.1538-7836.2008.02937.x

実験手法

X-RAY DIFFRACTION (1.8 Å)