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3BUV

Crystal structure of human Delta(4)-3-ketosteroid 5-beta-reductase in complex with NADP and HEPES. Resolution: 1.35 A.

Summary for 3BUV
Entry DOI10.2210/pdb3buv/pdb
Related3BUR
Descriptor3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (5 entities in total)
Functional Keywords5-beta-reductase; catalytic tetrad; e120; hepes; nadp, bile acid catabolism, disease mutation, lipid metabolism, oxidoreductase, steroid metabolism
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P51857
Total number of polymer chains2
Total formula weight76765.10
Authors
Di Costanzo, L.,Drury, J.,Penning, T.M.,Christianson, D.W. (deposition date: 2008-01-03, release date: 2008-04-01, Last modification date: 2023-08-30)
Primary citationDi Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W.
Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis.
J.Biol.Chem., 283:16830-16839, 2008
Cited by
PubMed: 18407998
DOI: 10.1074/jbc.M801778200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.35 Å)
Structure validation

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