3BUV
Crystal structure of human Delta(4)-3-ketosteroid 5-beta-reductase in complex with NADP and HEPES. Resolution: 1.35 A.
Summary for 3BUV
Entry DOI | 10.2210/pdb3buv/pdb |
Related | 3BUR |
Descriptor | 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (5 entities in total) |
Functional Keywords | 5-beta-reductase; catalytic tetrad; e120; hepes; nadp, bile acid catabolism, disease mutation, lipid metabolism, oxidoreductase, steroid metabolism |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P51857 |
Total number of polymer chains | 2 |
Total formula weight | 76765.10 |
Authors | Di Costanzo, L.,Drury, J.,Penning, T.M.,Christianson, D.W. (deposition date: 2008-01-03, release date: 2008-04-01, Last modification date: 2023-08-30) |
Primary citation | Di Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W. Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis. J.Biol.Chem., 283:16830-16839, 2008 Cited by PubMed: 18407998DOI: 10.1074/jbc.M801778200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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