3BT2

Structure of urokinase receptor, urokinase and vitronectin complex

Summary for 3BT2

• Entry DOI: 10.2210/pdb3bt2/pdb
• Related: 2fd6 3BT1
• Descriptor: Urokinase-type plasminogen activator, Vitronectin, anti-uPAR antibody, light chain, ... (8 entities in total)
• Functional Keywords: protein-protein interaction, glycoprotein, gpi-anchor, lipoprotein, membrane, receptor, secreted, blood coagulation, egf-like domain, fibrinolysis, hydrolase, kringle, phosphoprotein, plasminogen activation, protease, serine protease, zymogen, cell adhesion, heparin-binding, sulfation, immunoglobulin domain, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 98915.33

Authors

Huang, M. (deposition date: 2007-12-27, release date: 2008-03-25, Last modification date: 2024-11-13)

Primary citation

Huai, Q.,Zhou, A.,Lin, L.,Mazar, A.P.,Parry, G.C.,Callahan, J.,Shaw, D.E.,Furie, B.,Furie, B.C.,Huang, M.
Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Nat.Struct.Mol.Biol., 15:422-423, 2008

PubMed Abstract: The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.

PubMed: 18376415
DOI: 10.1038/nsmb.1404

Experimental method

X-RAY DIFFRACTION (2.5 Å)