3BT2

Structure of urokinase receptor, urokinase and vitronectin complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Urokinase-type plasminogen activator	polymer	135	15359.3	1	UniProt (P00749) Pfam (PF00051)	Homo sapiens (human)	uPA, U-plasminogen activator
2	B (B)	Vitronectin	polymer	40	4573.1	1	UniProt (P04004) Pfam (PF01033)	Homo sapiens (human)	Serum-spreading factor, S-protein, V75
3	C (L)	anti-uPAR antibody, light chain	polymer	212	23269.7	1	Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (P01675) UniProt (by SIFTS) (P01837)	Mus musculus (house mouse)
4	D (H)	anti-uPAR antibody, heavy chain	polymer	214	23041.7	1		Mus musculus (house mouse)
5	E (U)	Urokinase plasminogen activator surface receptor	polymer	283	31601.5	1	UniProt (Q03405) Pfam (PF00021)	Homo sapiens (human)	uPAR, U-PAR, Monocyte activation antigen Mo3, CD87 antigen
6	F, G (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
7	H (U)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
8	I, J, K, L (A, L, H, U)	water	water		18.0	57	Chemie (HOH)

Sequence modifications

A: 1 - 133 (UniProt: P00749)

PDB	External Database	Details
Arg -1	-	expression tag
Ser 0	-	expression tag

U: 1 - 281 (UniProt: Q03405)

PDB	External Database	Details
Arg 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	97845.3
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	98915.3

*Water molecules are not included.