3BT2

Structure of urokinase receptor, urokinase and vitronectin complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005044	molecular_function	scavenger receptor activity
B	0006955	biological_process	immune response
B	0030247	molecular_function	polysaccharide binding
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0019814	cellular_component	immunoglobulin complex
L	0030183	biological_process	B cell differentiation
L	0042105	cellular_component	alpha-beta T cell receptor complex
L	0071735	cellular_component	IgG immunoglobulin complex
U	0001934	biological_process	positive regulation of protein phosphorylation
U	0005102	molecular_function	signaling receptor binding
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005788	cellular_component	endoplasmic reticulum lumen
U	0005789	cellular_component	endoplasmic reticulum membrane
U	0005886	cellular_component	plasma membrane
U	0005925	cellular_component	focal adhesion
U	0006935	biological_process	chemotaxis
U	0007165	biological_process	signal transduction
U	0007596	biological_process	blood coagulation
U	0009897	cellular_component	external side of plasma membrane
U	0009986	cellular_component	cell surface
U	0010755	biological_process	regulation of plasminogen activation
U	0016020	cellular_component	membrane
U	0019898	cellular_component	extrinsic component of membrane
U	0019899	molecular_function	enzyme binding
U	0019904	molecular_function	protein domain specific binding
U	0030155	biological_process	regulation of cell adhesion
U	0030162	biological_process	regulation of proteolysis
U	0030377	molecular_function	urokinase plasminogen activator receptor activity
U	0031639	biological_process	plasminogen activation
U	0034112	biological_process	positive regulation of homotypic cell-cell adhesion
U	0034394	biological_process	protein localization to cell surface
U	0035579	cellular_component	specific granule membrane
U	0038023	molecular_function	signaling receptor activity
U	0038195	biological_process	urokinase plasminogen activator signaling pathway
U	0042995	cellular_component	cell projection
U	0043066	biological_process	negative regulation of apoptotic process
U	0043388	biological_process	positive regulation of DNA binding
U	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
U	0051917	biological_process	regulation of fibrinolysis
U	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
U	0098552	cellular_component	side of membrane
U	2000117	biological_process	obsolete negative regulation of cysteine-type endopeptidase activity
U	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00021
Number of Residues	13
Details	KRINGLE_1 Kringle domain signature. YCRNpdnrrrp.WC

Chain	Residue	Details
A	TYR101-CYS113

---

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CnCpkKfgGQhC

Chain	Residue	Details
A	CYS31-CYS42

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR191-HIS197

---

site_id	PS00524
Number of Residues	21
Details	SMB_1 Somatomedin B domain (SMB) signature. CqCdelCsyyqs.CCtDYtaeC

Chain	Residue	Details
B	CYS19-CYS39

---

site_id	PS00983
Number of Residues	44
Details	LY6_UPAR Ly-6 / u-PAR domain signature. RCMqCktngd...Crve.....ECAlgqdlCrttivrlweegeelelveks....C

Chain	Residue	Details
U	ARG2-CYS45
U	GLU94-CYS147
U	GLN193-CYS247

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	81
Details	Domain: {"description":"Kringle","evidences":[{"source":"PROSITE-ProRule","id":"PRU00121","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	23
Details	Region: {"description":"Binds urokinase plasminogen activator surface receptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (Fuc) threonine","evidences":[{"source":"PubMed","id":"2023947","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Cleavage; by U-PA"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15861141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16456079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22285761","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15861141","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15861141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16456079","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22285761","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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