3BP4
The high resolution crystal structure of HLA-B*2705 in complex with a Cathepsin A signal sequence peptide pCatA
Summary for 3BP4
Entry DOI | 10.2210/pdb3bp4/pdb |
Related | 3BP7 |
Descriptor | HLA class I histocompatibility antigen, B-27 alpha chain, Beta-2-microglobulin, nonameric peptide from Lysosomal protective protein, ... (5 entities in total) |
Functional Keywords | major histocompatibility complex, mhc, human leukocyte antigen, hla, beta-2-microglobulin, b2m, cathepsin a, pcata, ankylosing spondylitis, glycoprotein, host-virus interaction, immune response, membrane, mhc i, transmembrane, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, carboxypeptidase, hydrolase, lysosome, protease, zymogen, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P03989 Secreted . Note=(Microbial infection) In the presence of M: P61769 Lysosome: P10619 |
Total number of polymer chains | 3 |
Total formula weight | 44973.90 |
Authors | Kumar, P.,Vahedi-Faridi, A.,Saenger, W.,Uchanska-Ziegler, B.,Ziegler, A. (deposition date: 2007-12-18, release date: 2008-12-23, Last modification date: 2023-11-01) |
Primary citation | Kumar, P.,Vahedi-Faridi, A.,Saenger, W.,Merino, E.,Lopez de Castro, J.A.,Uchanska-Ziegler, B.,Ziegler, A. Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens J.Biol.Chem., 284:29784-29797, 2009 Cited by PubMed: 19617632DOI: 10.1074/jbc.M109.038497 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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