3BJC

Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor

3BJC の概要

• エントリーDOI: 10.2210/pdb3bjc/pdb
• 分子名称: cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: pde5, erectile dysfunction, inhibitor design, allosteric enzyme, alternative splicing, cgmp, cgmp-binding, hydrolase, magnesium, metal-binding, nucleotide-binding, phosphoprotein, polymorphism, zinc
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 100907.33

構造登録者

Chen, G.,Wang, H.,Howard, R.,Cai, J.,Wan, Y.,Ke, H. (登録日: 2007-12-03, 公開日: 2008-04-29, 最終更新日: 2024-04-03)

• 主引用文献: Chen, G.,Wang, H.,Robinson, H.,Cai, J.,Wan, Y.,Ke, H.; An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies; BIOCHEM.PHARM., 75:1717-1728, 2008; PubMed: 18346713; DOI: 10.1016/j.bcp.2008.01.019

実験手法

X-RAY DIFFRACTION (2 Å)