3BIV

Human thrombin-in complex with UB-THR11

3BIV の概要

• エントリーDOI: 10.2210/pdb3biv/pdb
• 関連するPDBエントリー: 1K1O 1K22 1YPG 2ZC9 2ZDA 3BIU
• 関連するBIRD辞書のPRD_ID: PRD_000587
• 分子名称: Thrombin light chain, Thrombin heavy chain, Hirudin, ... (6 entities in total)
• 機能のキーワード: serine protease-inhibitor complex, blood clotting, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, kringle, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35168.15

構造登録者

Gerlach, C.,Smolinski, M.,Steuber, H.,Sotriffer, C.A.,Heine, A.,Hangauer, D.G.,Klebe, G. (登録日: 2007-12-01, 公開日: 2007-12-25, 最終更新日: 2023-11-15)

• 主引用文献: Gerlach, C.,Smolinski, M.,Steuber, H.,Sotriffer, C.A.,Heine, A.,Hangauer, D.G.,Klebe, G.; Thermodynamic Inhibition Profile of a Cyclopentyl and a Cyclohexyl Derivative towards Thrombin: The Same but for Different Reasons; Angew.Chem.Int.Ed.Engl., 46:8511-8514, 2007; PubMed: 17902081; DOI: 10.1002/anie.200701169

実験手法

X-RAY DIFFRACTION (1.8 Å)