3BIS

Crystal Structure of the PD-L1

Summary for 3BIS

Related3BIK
DescriptorProgrammed cell death 1 ligand 1 (2 entities in total)
Functional Keywordsco-stimulation, immunoglobulin-like beta-sandwich, t cell, b cell, programmed death, immune system, transmembrane, inhibitory receptor, glycoprotein, immunoglobulin domain
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endomembrane system; Single-pass type I membrane protein Q9NZQ7
Total number of polymer chains2
Total molecular weight50793.56
Authors
Lin, D.Y.,Tanaka, Y.,Iwasaki, M.,Gittis, A.G.,Su, H.P.,Mikami, B.,Okazaki, T.,Honjo, T.,Minato, N.,Garboczi, D.N. (deposition date: 2007-11-30, release date: 2008-02-26, Last modification date: 2011-07-13)
Primary citation
Lin, D.Y.,Tanaka, Y.,Iwasaki, M.,Gittis, A.G.,Su, H.P.,Mikami, B.,Okazaki, T.,Honjo, T.,Minato, N.,Garboczi, D.N.
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors.
Proc.Natl.Acad.Sci.Usa, 105:3011-3016, 2008
PubMed: 18287011 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0712278105
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.64 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.29483.1%11.7%1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution