3BIK

Crystal Structure of the PD-1/PD-L1 Complex

Summary for 3BIK

• Entry DOI: 10.2210/pdb3bik/pdb
• Related: 3BIS
• Descriptor: Programmed cell death 1 ligand 1, Programmed cell death protein 1, GLYCEROL, ... (4 entities in total)
• Functional Keywords: co-stimulation, receptor-ligand complex, immunoglobulin-like beta-sandwich, t cell, b cell, programmed death, immune system, transmembrane, inhibitory receptor, glycoprotein, immunoglobulin domain, apoptosis
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endomembrane system; Single-pass type I membrane protein: Q9NZQ7; Membrane; Single-pass type I membrane protein: Q02242
• Total number of polymer chains: 3
• Total formula weight: 55672.53

Authors

Lin, D.Y.,Tanaka, Y.,Iwasaki, M.,Gittis, A.G.,Su, H.P.,Mikami, B.,Okazaki, T.,Honjo, T.,Minato, N.,Garboczi, D.N. (deposition date: 2007-11-30, release date: 2008-02-26, Last modification date: 2023-08-30)

• Primary citation: Lin, D.Y.,Tanaka, Y.,Iwasaki, M.,Gittis, A.G.,Su, H.P.,Mikami, B.,Okazaki, T.,Honjo, T.,Minato, N.,Garboczi, D.N.; The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors.; Proc.Natl.Acad.Sci.Usa, 105:3011-3016, 2008; PubMed: 18287011; DOI: 10.1073/pnas.0712278105

Experimental method

X-RAY DIFFRACTION (2.65 Å)