3BIC

Crystal structure of human methylmalonyl-CoA mutase

Summary for 3BIC

• Entry DOI: 10.2210/pdb3bic/pdb
• Related: 1REQ
• Descriptor: Methylmalonyl-CoA mutase, mitochondrial precursor, CHLORIDE ION (3 entities in total)
• Functional Keywords: organic aciduria, methylmalonyl coa mutase deficiency, metabolic disease, structural genomics, structural genomics consortium, sgc, cobalamin, cobalt, disease mutation, isomerase, metal-binding, mitochondrion, transit peptide
• Biological source: Homo sapiens (human)
• Cellular location: Mitochondrion matrix: P22033
• Total number of polymer chains: 2
• Total formula weight: 169813.45

Authors

Ugochukwu, E.,Kochan, G.,Pantic, N.,Parizotto, E.,Pilka, E.S.,Pike, A.C.W.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.M.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2007-11-30, release date: 2007-12-25, Last modification date: 2023-08-30)

• Primary citation: Froese, D.S.,Kochan, G.,Muniz, J.R.,Wu, X.,Gileadi, C.,Ugochukwu, E.,Krysztofinska, E.,Gravel, R.A.,Oppermann, U.,Yue, W.W.; Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.; J.Biol.Chem., 285:38204-38213, 2010; PubMed: 20876572; DOI: 10.1074/jbc.M110.177717

Experimental method

X-RAY DIFFRACTION (2.6 Å)