3BHT

Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3

3BHT の概要

• エントリーDOI: 10.2210/pdb3bht/pdb
• 関連するPDBエントリー: 3BHU 3BHV
• 分子名称: Cell division protein kinase 2, Cyclin-A2, 4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, ... (6 entities in total)
• 機能のキーワード: ser/thr protein kinase, transferase, phosphorylation, cell cycle, atp-binding, cell division, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, cyclin
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P30274
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 129294.05

構造登録者

Echalier, A.,Bettayeb, K.,Ferandin, Y.,Lozach, O.,Clement, M.,Valette, A.,Liger, F.,Marquet, B.,Morris, J.C.,Endicott, J.A.,Joseph, B.,Meijer, L. (登録日: 2007-11-29, 公開日: 2008-02-12, 最終更新日: 2011-07-13)

• 主引用文献: Bettayeb, K.,Tirado, O.M.,Marionneau-Lambot, S.,Ferandin, Y.,Lozach, O.,Morris, J.C.,Mateo-Lozano, S.,Drueckes, P.,Kubbutat, M.H.,Liger, F.,Marquet, B.,Joseph, B.,Echalier, A.,Endicott, J.A.,Notario, V.,Meijer, L.; Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases; Cancer Res., 67:8325-8334, 2007; PubMed: 17804748; DOI: 10.1158/0008-5472.CAN-07-1826

実験手法

X-RAY DIFFRACTION (2 Å)