3BGC
HIV-1 protease in complex with a benzyl decorated oligoamine
Summary for 3BGC
| Entry DOI | 10.2210/pdb3bgc/pdb |
| Related | 3BGB |
| Descriptor | Protease, N,N'-(iminodiethane-2,1-diyl)bis(4-amino-N-benzylbenzenesulfonamide), CHLORIDE ION, ... (4 entities in total) |
| Functional Keywords | protein-ligand complex, aids, aspartyl protease, capsid maturation, core protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger |
| Biological source | Human immunodeficiency virus type 1 (Viruses) |
| Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
| Total number of polymer chains | 2 |
| Total formula weight | 22272.18 |
| Authors | Boettcher, J.,Blum, A.,Sammet, B.,Heine, A.,Diederich, W.E.,Klebe, G. (deposition date: 2007-11-26, release date: 2008-09-02, Last modification date: 2023-11-01) |
| Primary citation | Blum, A.,Sammet, B.,Luksch, T.,Heine, A.,Klebe, G.,Diederich, W.E. Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors Bioorg.Med.Chem., 16:8574-8586, 2008 Cited by PubMed: 18760609DOI: 10.1016/j.bmc.2008.08.012 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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