3BEJ

Structure of human FXR in complex with MFA-1 and co-activator peptide

3BEJ の概要

• エントリーDOI: 10.2210/pdb3bej/pdb
• 分子名称: Bile acid receptor, Nuclear receptor coactivator 1, YTTRIUM (III) ION, ... (5 entities in total)
• 機能のキーワード: fxr, bar, nr1h4, bile acid receptor, nhr, nuclear receptor, activator, alternative splicing, dna-binding, metal-binding, nucleus, repressor, transcription, transcription regulation, zinc, zinc-finger, acyltransferase, chromosomal rearrangement, phosphoprotein, polymorphism, proto-oncogene, transferase, ubl conjugation, transcription-transferase complex, transcription regulator
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 62313.21

構造登録者

Soisson, S.M.,Parthasarathy, G.,Becker, J.W. (登録日: 2007-11-19, 公開日: 2008-03-18, 最終更新日: 2024-02-21)

• 主引用文献: Soisson, S.M.,Parthasarathy, G.,Adams, A.D.,Sahoo, S.,Sitlani, A.,Sparrow, C.,Cui, J.,Becker, J.W.; Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation.; Proc.Natl.Acad.Sci.Usa, 105:5337-5342, 2008; PubMed: 18391212; DOI: 10.1073/pnas.0710981105

実験手法

X-RAY DIFFRACTION (1.9 Å)