3BDX
Crystal structure of the unstable and highly fibrillogenic Pro7Ser mutant of the Recombinant variable domain 6AJL2
Summary for 3BDX
Entry DOI | 10.2210/pdb3bdx/pdb |
Descriptor | Amyloid lambda 6 light chain variable region PIP (fragment), ACETATE ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | lambda vi subgroup, light chain variable domain, beta-sandwich, immunoglobulin, al amyloidosis, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 36714.45 |
Authors | Hernandez-Santoyo, A.,Fuentes-Silva, D.,Del Pozo Yauner, L.,Becerril, B.,Rodriguez-Romero, A. (deposition date: 2007-11-15, release date: 2008-10-28, Last modification date: 2023-08-30) |
Primary citation | Hernandez-Santoyo, A.,del Pozo Yauner, L.,Fuentes-Silva, D.,Ortiz, E.,Rudino-Pinera, E.,Sanchez-Lopez, R.,Horjales, E.,Becerril, B.,Rodriguez-Romero, A. A single mutation at the sheet switch region results in conformational changes favoring lambda6 light-chain fibrillogenesis. J.Mol.Biol., 396:280-292, 2010 Cited by PubMed: 19941869DOI: 10.1016/j.jmb.2009.11.038 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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