3BDX

Crystal structure of the unstable and highly fibrillogenic Pro7Ser mutant of the Recombinant variable domain 6AJL2

3BDX の概要

• エントリーDOI: 10.2210/pdb3bdx/pdb
• 分子名称: Amyloid lambda 6 light chain variable region PIP (fragment), ACETATE ION, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: lambda vi subgroup, light chain variable domain, beta-sandwich, immunoglobulin, al amyloidosis, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 36714.45

構造登録者

Hernandez-Santoyo, A.,Fuentes-Silva, D.,Del Pozo Yauner, L.,Becerril, B.,Rodriguez-Romero, A. (登録日: 2007-11-15, 公開日: 2008-10-28, 最終更新日: 2023-08-30)

• 主引用文献: Hernandez-Santoyo, A.,del Pozo Yauner, L.,Fuentes-Silva, D.,Ortiz, E.,Rudino-Pinera, E.,Sanchez-Lopez, R.,Horjales, E.,Becerril, B.,Rodriguez-Romero, A.; A single mutation at the sheet switch region results in conformational changes favoring lambda6 light-chain fibrillogenesis.; J.Mol.Biol., 396:280-292, 2010; PubMed: 19941869; DOI: 10.1016/j.jmb.2009.11.038

実験手法

X-RAY DIFFRACTION (2.3 Å)