3BAR

Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase covalently modified by 6-azido-UMP

3BAR の概要

• エントリーDOI: 10.2210/pdb3bar/pdb
• 関連するPDBエントリー: 2Q8L 2Q8Z 2QAF
• 分子名称: Orotidine 5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE (3 entities in total)
• 機能のキーワード: plasmodium falciparum, orotidine 5'-phosphate decarboxylase, covalently, 6-azido-ump, lyase, pyrimidine biosynthesis
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80447.28

構造登録者

Liu, Y.,Bello, A.M.,Poduch, E.,Lau, W.,Kotra, L.P.,Pai, E.F. (登録日: 2007-11-08, 公開日: 2008-01-29, 最終更新日: 2023-08-30)

• 主引用文献: Bello, A.M.,Poduch, E.,Liu, Y.,Wei, L.,Crandall, I.,Wang, X.,Dyanand, C.,Kain, K.C.,Pai, E.F.,Kotra, L.P.; Structure-Activity Relationships of C6-Uridine Derivatives Targeting Plasmodia Orotidine Monophosphate Decarboxylase.; J.Med.Chem., 51:439-448, 2008; PubMed: 18189347; DOI: 10.1021/jm7010673

実験手法

X-RAY DIFFRACTION (1.9 Å)