3B9Q
The crystal structure of cpFtsY from Arabidopsis thaliana
Summary for 3B9Q
| Entry DOI | 10.2210/pdb3b9q/pdb |
| Descriptor | Chloroplast SRP receptor homolog, alpha subunit CPFTSY, MALONATE ION (3 entities in total) |
| Functional Keywords | cpftsy, srp receptor, protein translocation, gtp-binding, nucleotide-binding, protein transport |
| Biological source | Arabidopsis thaliana (thale cress) |
| Total number of polymer chains | 1 |
| Total formula weight | 32704.68 |
| Authors | Stengel, K.F.,Wild, K.,Sinning, I. (deposition date: 2007-11-06, release date: 2007-12-25, Last modification date: 2023-11-01) |
| Primary citation | Stengel, K.F.,Holdermann, I.,Wild, K.,Sinning, I. The structure of the chloroplast signal recognition particle (SRP) receptor reveals mechanistic details of SRP GTPase activation and a conserved membrane targeting site Febs Lett., 581:5671-5676, 2007 Cited by PubMed Abstract: Two GTPases in the signal recognition particle and its receptor (FtsY) regulate protein targeting to the membrane by formation of a heterodimeric complex. The activation of both GTPases in the complex is essential for protein translocation. We present the crystal structure of chloroplast FtsY (cpFtsY) at 1.75 A resolution. The comparison with FtsY structures in different nucleotide bound states shows structural changes relevant for GTPase activation and provides insights in how cpFtsY is pre-organized for complex formation with cpSRP54. The structure contains an amino-terminal amphipathic helix similar to the membrane targeting sequence of Escherichia coli FtsY. In cpFtsY this motif is extended, which might be responsible for the enhanced attachment of the protein to the thylakoid membrane. PubMed: 18022392DOI: 10.1016/j.febslet.2007.11.024 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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