3B99

Crystal structure of zebrafish prostacyclin synthase (cytochrome P450 8A1) in complex with substrate analog U51605

3B99 の概要

• エントリーDOI: 10.2210/pdb3b99/pdb
• 関連するPDBエントリー: 3B6H 3B98
• 分子名称: Prostaglandin I2 synthase, PROTOPORPHYRIN IX CONTAINING FE, (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-oct-1-en-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}hept-5-enoic acid, ... (4 entities in total)
• 機能のキーワード: prostacyclin synthase, cytochrome p450 8a1, cyp8a1, substrate analog-enzyme complex, isomerase
• 由来する生物種: Danio rerio (zebrafish)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 112925.71

構造登録者

Li, Y.-C.,Chiang, C.-W.,Yeh, H.-C.,Hsu, P.-Y.,Whitby, F.G.,Wang, L.-H.,Chan, N.-L. (登録日: 2007-11-03, 公開日: 2007-11-20, 最終更新日: 2023-11-01)

• 主引用文献: Li, Y.-C.,Chiang, C.-W.,Yeh, H.-C.,Hsu, P.-Y.,Whitby, F.G.,Wang, L.-H.,Chan, N.-L.; Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change; J.Biol.Chem., 283:2917-2926, 2008; PubMed: 18032380; DOI: 10.1074/jbc.M707470200

実験手法

X-RAY DIFFRACTION (2.5 Å)