3B80
HIV-1 protease mutant I54V complexed with gem-diol-amine intermediate NLLTQI
Summary for 3B80
Entry DOI | 10.2210/pdb3b80/pdb |
Related | 3B7V |
Related PRD ID | PRD_000321 |
Descriptor | Protease, peptide, SODIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase substrate complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 BH10 More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04587 |
Total number of polymer chains | 3 |
Total formula weight | 22301.49 |
Authors | Chumanevich, A.A.,Kovalevsky, A.Y.,Weber, I.T. (deposition date: 2007-10-31, release date: 2007-12-18, Last modification date: 2023-08-30) |
Primary citation | Kovalevsky, A.Y.,Chumanevich, A.A.,Liu, F.,Louis, J.M.,Weber, I.T. Caught in the Act: The 1.5 A Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate. Biochemistry, 46:14854-14864, 2007 Cited by PubMed: 18052235DOI: 10.1021/bi700822g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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