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3B7O

Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site

Summary for 3B7O
Entry DOI10.2210/pdb3b7o/pdb
Related2SHP
DescriptorTyrosine-protein phosphatase non-receptor type 11, D-MALATE (3 entities in total)
Functional Keywordsshp2, ptpn11, tyrosine phosphatase, structural genomics, structural genomics consortium, sgc, deafness, disease mutation, hydrolase, phosphorylation, protein phosphatase, sh2 domain
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : Q06124
Total number of polymer chains1
Total formula weight37013.81
Authors
Primary citationBarr, A.J.,Ugochukwu, E.,Lee, W.H.,King, O.N.,Filippakopoulos, P.,Alfano, I.,Savitsky, P.,Burgess-Brown, N.A.,Muller, S.,Knapp, S.
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136:352-363, 2009
Cited by
PubMed: 19167335
DOI: 10.1016/j.cell.2008.11.038
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

217705

数据于2024-03-27公开中

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