3B7O

Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site

3B7O の概要

• エントリーDOI: 10.2210/pdb3b7o/pdb
• 関連するPDBエントリー: 2SHP
• 分子名称: Tyrosine-protein phosphatase non-receptor type 11, D-MALATE (3 entities in total)
• 機能のキーワード: shp2, ptpn11, tyrosine phosphatase, structural genomics, structural genomics consortium, sgc, deafness, disease mutation, hydrolase, phosphorylation, protein phosphatase, sh2 domain
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q06124
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37013.81

構造登録者

Ugochukwu, E.,Barr, A.,Patel, A.,King, O.,Niesen, F.,Salah, E.,Savitsky, P.,Pilka, E.S.,Elkins, J.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.M.,von Delft, F.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2007-10-31, 公開日: 2007-11-13, 最終更新日: 2023-08-30)

• 主引用文献: Barr, A.J.,Ugochukwu, E.,Lee, W.H.,King, O.N.,Filippakopoulos, P.,Alfano, I.,Savitsky, P.,Burgess-Brown, N.A.,Muller, S.,Knapp, S.; Large-scale structural analysis of the classical human protein tyrosine phosphatome.; Cell(Cambridge,Mass.), 136:352-363, 2009; PubMed: 19167335; DOI: 10.1016/j.cell.2008.11.038

実験手法

X-RAY DIFFRACTION (1.6 Å)