3B71

CD4 endocytosis motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase

Summary for 3B71

Entry DOI	10.2210/pdb3b71/pdb
Related	1K04 1K05 1OW6 1OW7 1OW8
Descriptor	Focal adhesion kinase 1, T-cell surface glycoprotein CD4 (2 entities in total)
Functional Keywords	four-helix bundle, protein-protein complex, atp-binding, cell junction, kinase, nucleotide-binding, phosphorylation, transferase, tyrosine-protein kinase, glycoprotein, host-virus interaction, immune response, immunoglobulin domain, lipoprotein, membrane, palmitate, transmembrane, protein binding
Biological source	Homo sapiens (human)
Cellular location	Cell junction, focal adhesion: Q05397 Cell membrane; Single-pass type I membrane protein: P01730
Total number of polymer chains	6
Total formula weight	62184.00
Authors	Garron, M.-L.,Arold, S.T. (deposition date: 2007-10-30, release date: 2008-01-01, Last modification date: 2023-08-30)
Primary citation	Garron, M.L.,Arthos, J.,Guichou, J.F.,McNally, J.,Cicala, C.,Arold, S.T. Structural basis for the interaction between focal adhesion kinase and CD4. J.Mol.Biol., 375:1320-1328, 2008 Cited by PubMed: 18078954 DOI: 10.1016/j.jmb.2007.11.040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.82 Å)

Structure validation