3B6O

Structure of TREX1 in complex with a nucleotide and an inhibitor ion (lithium)

Summary for 3B6O

Entry DOI	10.2210/pdb3b6o/pdb
Related	1Y97 2IOC 2O4G 2O4I 2OA8 3B6P
Descriptor	Three prime repair exonuclease 1, LITHIUM ION, THYMIDINE-5'-PHOSPHATE, ... (4 entities in total)
Functional Keywords	trex1, dedd, exonuclease, dnaq, lithium, catalysis, inhibition, deoxy-thimidine monophosphate (dtmp), dna damage, dna repair, hydrolase, magnesium, nucleus, phosphorylation
Biological source	Mus musculus (Mouse)
Cellular location	Nucleus (By similarity): Q91XB0
Total number of polymer chains	4
Total formula weight	110008.64
Authors	Brucet, M.,Querol-Audi, J.,Fita, I.,Celada, A. (deposition date: 2007-10-29, release date: 2008-09-23, Last modification date: 2023-08-30)
Primary citation	Brucet, M.,Querol-Audi, J.,Bertlik, K.,Lloberas, J.,Fita, I.,Celada, A. Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases. Protein Sci., 17:2059-2069, 2008 Cited by PubMed: 18780819 DOI: 10.1110/ps.036426.108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation